Here is the default 64 bit plug-in location for Spectrasonics Instruments on Windows: If you are running a 64 bit host, make sure that you run all of the updates from your User Account (Software, Patch Library, and Soundsource Library), and if using Windows, you are selecting the correct location for the updated. If you are running a 32 bit host, or 32 bit operating system, Omnisphere 2.5 and above will not work. Omnisphere 2.5 and above require a 64 bit host.